Embryonic heart tube development

Across TCGA cell cohorts, RNA activity of the Embryonic heart tube development pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARD6A, ATP13A3, and TAF1L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic heart tube development activity versus PARD6A in LIVER (Pearson r = -0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PARD6A →	-1.531	-0.184	.001	.001	3	6
LIVER	ATP13A3 →	+1.268	+0.170	.005	.005	3	5
OVARY	TAF1L →	-0.053	-0.257	.002	.004	3	4
LARGE_INTESTINE	ZMYM1 →	-0.665	-0.150	.001	.003	3	4
BREAST	IQCB1 →	-0.730	-0.258	.007	.004	2	5
STOMACH	TFAP4 →	-1.114	-0.286	.004	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035050 vs PARD6A — LIVER

Explore this scatter interactively →