Sperm-egg recognition

Across TCGA patient cohorts, RNA activity of the Sperm-egg recognition pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FOLR2, GIMAP8, and MDH2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm-egg recognition activity versus FOLR2 in GBM (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FOLR2 →	+0.806	+0.087	<.001	<.001	3	7
GBM	GIMAP8 →	+0.459	+0.067	<.001	<.001	3	7
LSCC	MDH2 →	-0.327	-0.090	<.001	<.001	3	7
LSCC	PNPT1 →	-0.279	-0.055	.001	<.001	3	7
OV	DOK2 →	+0.519	+0.053	.001	.002	3	6
LUAD	SSBP1 →	-0.307	-0.053	.002	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035036 vs FOLR2 — GBM

Explore this scatter interactively →