Sperm-egg recognition

Across TCGA cell cohorts, RNA activity of the Sperm-egg recognition pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNE1, SPATA20, and TOPORS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCNE1 grouped by Sperm-egg recognition-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCNE1 →	+0.706	+0.735	.008	.006	3	5
SKIN	SPATA20 →	-0.747	-0.840	<.001	.002	3	5
BLOOD_Myeloma	TOPORS →	+0.734	+1.513	.002	.002	3	4
STOMACH	IDUA →	-1.429	-0.231	.001	.001	3	3
LUNG_SCLC	ARHGEF16 →	-1.883	-0.228	<.001	.006	3	3
KIDNEY	MVP →	-0.805	-0.965	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCNE1 by Sperm-egg recognition activity — BLOOD_Leukemia

Explore this box plot interactively →