Sperm-egg recognition

Across TCGA cell cohorts, RNA activity of the Sperm-egg recognition pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX2, ABI2, and DYRK3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm-egg recognition activity versus STX2 in LUNG_NSCLC_LUAD (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	STX2 →	+1.476	+0.186	<.001	<.001	3	7
STOMACH	ABI2 →	+0.855	+0.193	.001	.004	3	6
STOMACH	DYRK3 →	+1.692	+0.248	.003	.003	3	6
BLOOD_Myeloma	RTL6 →	+2.609	+0.280	<.001	<.001	3	6
BLOOD_Myeloma	SNX27 →	+1.547	+0.311	.004	.004	3	6
SKIN	UBAP2L →	+0.872	+0.244	.002	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035036 vs STX2 — LUNG_NSCLC_LUAD

Explore this scatter interactively →