Sperm-egg recognition

Across TCGA cell cohorts, RNA activity of the Sperm-egg recognition pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EEF1B2, UBAP2L, and CACYBP, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sperm-egg recognition activity versus EEF1B2 in URINARY_TRACT (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	EEF1B2 →	+1.715	+0.308	<.001	.003	3	15
STOMACH	UBAP2L →	+1.511	+0.338	<.001	<.001	3	15
URINARY_TRACT	CACYBP →	+2.107	+0.260	.008	<.001	3	14
URINARY_TRACT	ELOC →	+1.356	+0.276	<.001	.006	3	14
LARGE_INTESTINE	CAMKV →	+1.441	+0.170	<.001	.001	3	13
URINARY_TRACT	PGAM1 →	+3.481	+0.316	<.001	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035036 vs EEF1B2 — URINARY_TRACT

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