Positive regulation of Rho protein signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of Rho protein signal transduction pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, SLC17A2, and TSFM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GINS1 grouped by Positive regulation of Rho protein signal transduction-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GINS1 →	+0.340	+0.074	<.001	.006	3	5
BREAST	SLC17A2 →	+0.292	+0.080	.001	.001	3	4
LUNG_NSCLC_LUAD	TSFM →	-0.091	-0.067	.001	.007	3	4
LUNG_NSCLC_LUSC	CBX3 →	+0.172	+0.130	.006	.005	2	5
OVARY	REXO5 →	+0.136	+0.114	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	SLC5A11 →	+0.241	+0.059	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GINS1 by Positive regulation of Rho protein signal transduction activity — LARGE_INTESTINE

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