Positive regulation of Rho protein signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of Rho protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSR, GRB7, and KCTD7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Rho protein signal transduction activity versus LSR in LUNG_NSCLC_LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LSR →	+1.418	+0.222	.008	.003	3	6
BREAST	GRB7 →	+2.793	+0.271	<.001	<.001	3	5
BREAST	KCTD7 →	-0.543	-0.284	.001	<.001	3	5
BREAST	MKRN2 →	-0.588	-0.274	.001	.003	3	5
KIDNEY	ZFP1 →	-0.890	-0.349	<.001	.003	3	4
STOMACH	RAB17 →	+3.736	+0.462	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035025 vs LSR — LUNG_NSCLC_LUAD

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