Negative regulation of Rho protein signal transduction

Across TCGA patient cohorts, RNA activity of the Negative regulation of Rho protein signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPS2, FRZB, and PHLDB1_S404, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Rho protein signal transduction activity versus RPS2 in CCRCC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPS2 →	-0.200	-0.040	.001	<.001	3	8
BRCA	FRZB →	+0.733	+0.042	<.001	<.001	3	8
BRCA	PHLDB1_S404 →	+0.420	+0.031	.003	.002	3	8
BRCA	FERMT2 →	+0.640	+0.042	<.001	<.001	3	8
CCRCC	PRKG1 →	+0.517	+0.046	<.001	<.001	3	8
COAD	RAI14 →	+0.276	+0.041	.005	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035024 vs RPS2 — CCRCC

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