Negative regulation of Rho protein signal transduction

Across TCGA cell cohorts, RNA activity of the Negative regulation of Rho protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, SPOP, and LRRIQ1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of Rho protein signal transduction activity versus ANXA1 in BREAST (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ANXA1 →	+3.579	+0.958	.005	.006	3	4
BONE	SPOP →	+0.707	+0.329	<.001	.005	3	4
BREAST	LRRIQ1 →	+0.528	+0.671	.001	.004	3	3
BREAST	PDE3B →	-1.365	-1.369	<.001	<.001	3	3
PANCREAS	SACM1L →	-0.469	-0.251	.002	.005	2	4
CNS	ARL1 →	-0.555	-0.165	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035024 vs ANXA1 — BREAST

Explore this scatter interactively →