Regulation of Rho protein signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of Rho protein signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GGT5, KANK2, and RPS5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Rho protein signal transduction activity versus GGT5 in COAD (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GGT5 →	+0.544	+0.035	<.001	<.001	3	9
BRCA	KANK2 →	+0.459	+0.029	<.001	<.001	3	9
HNSC	RPS5 →	-0.170	-0.044	<.001	.005	3	8
GBM	SEPTIN4 →	+0.493	+0.037	.002	<.001	3	8
BRCA	TNS2 →	+0.323	+0.031	<.001	<.001	3	8
OV	COIL_T303 →	-1.034	-0.028	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035023 vs GGT5 — COAD

Explore this scatter interactively →