Regulation of Rho protein signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of Rho protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BANF1P4, ECHDC2, and NBL1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BANF1P4 grouped by Regulation of Rho protein signal transduction-low versus -high activity in OV.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BANF1P4 →	-0.834	-0.940	.007	<.001	3	3
UCEC	ECHDC2 →	+1.125	+1.984	<.001	.007	2	3
PDAC	NBL1 →	+0.974	+2.990	.002	<.001	2	3
CCRCC	SNORD83A →	+0.643	+1.275	.001	<.001	3	2
CCRCC	RN7SL814P →	+0.345	+0.840	.001	.005	3	2
HNSC	C2CD4A →	-1.031	-1.420	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035023 vs BANF1P4 — OV

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