Regulation of Rho protein signal transduction

Across TCGA cell cohorts, RNA activity of the Regulation of Rho protein signal transduction pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OXSR1, ZNF446, and SLC2A6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OXSR1 grouped by Regulation of Rho protein signal transduction-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OXSR1 →	+0.208	+0.294	.002	<.001	3	3
OVARY	ZNF446 →	+0.331	+0.254	<.001	.003	3	3
STOMACH	SLC2A6 →	+0.180	+0.290	.003	.003	3	3
BREAST	PRKX →	-0.158	-0.169	.002	.004	2	4
BLOOD_Leukemia	SLC22A11 →	-0.217	-0.240	.005	.005	3	3
OESOPHAGUS	PITPNA →	+0.129	+0.376	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OXSR1 by Regulation of Rho protein signal transduction activity — OVARY

Explore this box plot interactively →