Regulation of Rho protein signal transduction

Across TCGA cell cohorts, RNA activity of the Regulation of Rho protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KAZALD1, NUCB1, and PXYLP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Rho protein signal transduction activity versus KAZALD1 in BLOOD_Leukemia (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KAZALD1 →	-1.615	-0.202	.008	.003	3	5
BLOOD_Myeloma	NUCB1 →	-1.086	-0.390	.003	.003	3	4
UPPER_AERODIGESTIVE_TRACT	PXYLP1 →	-1.827	-0.239	.003	.005	2	5
KIDNEY	SLC2A4 →	-0.132	-0.183	.004	.005	2	4
UPPER_AERODIGESTIVE_TRACT	SYT15 →	-0.857	-0.255	.005	.001	3	3
OVARY	ANKRD20A3P →	+0.301	+0.162	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035023 vs KAZALD1 — BLOOD_Leukemia

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