Positive regulation of Rac protein signal transduction

Across TCGA patient cohorts, RNA activity of the Positive regulation of Rac protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM1, PRRG1, and RPL39L, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Rac protein signal transduction activity versus MDM1 in HNSC (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MDM1 →	+0.521	+0.851	.004	.001	3	3
HNSC	PRRG1 →	-0.649	-0.970	.007	.001	3	3
HNSC	RPL39L →	+1.234	+0.955	.002	.002	3	3
HNSC	RASA3-IT1 →	-0.706	-0.989	.001	.001	3	3
UCEC	RYR2 →	-0.620	-1.065	.004	.001	3	3
UCEC	MIR4503 →	+0.292	+1.061	.006	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035022 vs MDM1 — HNSC

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