Positive regulation of Rac protein signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of Rac protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SKIL, SPACA6, and FRYL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SKIL grouped by Positive regulation of Rac protein signal transduction-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SKIL →	+1.500	+1.717	.003	.002	3	4
BONE	SPACA6 →	+0.961	+1.742	.001	.001	3	3
BONE	FRYL →	+1.274	+1.709	.006	.003	3	3
BONE	ARHGAP28 →	+1.733	+1.235	<.001	.009	2	4
BLOOD_Leukemia	STARD8 →	+2.479	+1.314	.007	.001	3	3
BLOOD_Leukemia	NIBAN2 →	+1.881	+1.008	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SKIL by Positive regulation of Rac protein signal transduction activity — BONE

Explore this box plot interactively →