Positive regulation of Rac protein signal transduction

Across TCGA cell cohorts, RNA activity of the Positive regulation of Rac protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BOLA3, PRPF31, and CCT7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of Rac protein signal transduction activity versus BOLA3 in LUNG_SCLC (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BOLA3 →	+0.641	+0.296	.005	.002	3	8
LARGE_INTESTINE	PRPF31 →	+0.683	+0.219	.003	.009	3	6
LIVER	CCT7 →	+0.952	+0.392	.009	.004	2	7
SOFT_TISSUE	MAMSTR →	+3.585	+0.374	<.001	<.001	3	6
OVARY	TYMS →	+1.101	+0.247	.001	<.001	3	6
OVARY	DGUOK →	+0.501	+0.253	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035022 vs BOLA3 — LUNG_SCLC

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