Regulation of Rac protein signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of Rac protein signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KIF1B_S1487, DDX21, and OSBPL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Rac protein signal transduction activity versus KIF1B_S1487 in GBM (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KIF1B_S1487 →	-0.331	-0.063	.001	<.001	3	5
LUAD	DDX21 →	-0.365	-0.044	<.001	<.001	3	5
BRCA	OSBPL3 →	-0.307	-0.037	.003	<.001	3	5
HNSC	RPL7 →	-0.146	-0.058	.002	<.001	3	5
HNSC	HMGB1 →	+0.241	+0.050	<.001	<.001	3	5
HNSC	IRF2BP1 →	+0.272	+0.048	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035020 vs KIF1B_S1487 — GBM

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