Regulation of Rac protein signal transduction

Across TCGA patient cohorts, RNA activity of the Regulation of Rac protein signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLK3_S215, UBR5_S1549, and YIF1A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Rac protein signal transduction activity versus CLK3_S215 in COAD (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CLK3_S215 →	-0.691	-0.600	.003	.003	3	3
UCEC	UBR5_S1549 →	-0.465	-0.399	<.001	<.001	3	3
LSCC	YIF1A →	-0.437	-0.608	<.001	<.001	3	3
GBM	RPS6KA5 →	+0.374	+0.226	<.001	<.001	3	2
GBM	SHANK3 →	+0.522	+0.233	<.001	<.001	3	2
CCRCC	ATP11A_S495 →	+1.067	+1.931	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035020 vs CLK3_S215 — COAD

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