Regulation of Rac protein signal transduction

Across TCGA cell cohorts, RNA activity of the Regulation of Rac protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RANGAP1, MCM3, and SRSF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RANGAP1 grouped by Regulation of Rac protein signal transduction-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RANGAP1 →	-0.599	-1.208	.007	<.001	3	4
BLOOD_Leukemia	MCM3 →	-0.949	-1.265	.001	.001	3	4
BLOOD_Leukemia	SRSF2 →	-0.744	-1.410	<.001	<.001	3	4
BLOOD_Leukemia	RRP7A →	-0.841	-1.196	.001	.001	3	4
CNS	BTBD19 →	+1.429	+0.954	.002	.006	3	3
BLOOD_Lymphoma	MROH6 →	+1.807	+1.744	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RANGAP1 by Regulation of Rac protein signal transduction activity — BLOOD_Leukemia

Explore this box plot interactively →