Regulation of Rac protein signal transduction

Across TCGA cell cohorts, RNA activity of the Regulation of Rac protein signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RANGAP1, UBE3B, and CUL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Rac protein signal transduction activity versus RANGAP1 in CNS (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RANGAP1 →	+0.731	+0.241	.006	.003	3	6
BLOOD_Leukemia	UBE3B →	+0.405	+0.133	<.001	.006	3	5
BREAST	CUL2 →	+0.538	+0.201	.004	.002	3	5
OVARY	OVOL1 →	-1.428	-0.536	<.001	.004	3	5
LARGE_INTESTINE	FKBP7 →	+0.920	+0.401	.001	.005	3	5
URINARY_TRACT	PFDN1 →	+0.790	+0.217	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035020 vs RANGAP1 — CNS

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