Somatic stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Somatic stem cell population maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB33A, CMTM3, and VPS37A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAB33A grouped by Somatic stem cell population maintenance-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RAB33A →	+2.730	+1.681	<.001	<.001	3	3
BONE	CMTM3 →	-1.063	-1.437	.002	<.001	3	3
BONE	VPS37A →	-1.139	-1.590	.001	.001	3	3
BONE	PTPRM →	-3.531	-1.546	<.001	<.001	3	3
BONE	C17orf107 →	+0.804	+1.300	.001	.001	3	3
BONE	REST →	-0.820	-1.683	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAB33A by Somatic stem cell population maintenance activity — BONE

Explore this box plot interactively →