Somatic stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Somatic stem cell population maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HK1, PFN2, and MBD3, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Somatic stem cell population maintenance activity versus HK1 in LUNG_SCLC (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HK1 →	+1.900	+0.664	.006	.008	3	2
LUNG_SCLC	PFN2 →	-1.588	-0.604	.001	<.001	3	1
LUNG_SCLC	MBD3 →	-0.954	-0.771	.005	.002	3	1
LUNG_SCLC	RCOR1 →	-1.087	-0.604	<.001	<.001	3	1
LUNG_SCLC	ACOT7 →	-1.937	-0.604	.001	<.001	3	1
LUNG_SCLC	PPIL2 →	-0.830	-0.591	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035019 vs HK1 — LUNG_SCLC

Explore this scatter interactively →