Somatic stem cell population maintenance

Across TCGA cell cohorts, RNA activity of the Somatic stem cell population maintenance pathway is significantly associated with the drug response of multiple features, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are GSK1904529A, CCT245467, and Cyclopamine, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSK1904529A grouped by Somatic stem cell population maintenance-low versus -high activity in BONE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GSK1904529A →	-0.834	-1.380	.004	.034	2	3
LUNG_SCLC	CCT245467 →	+1.107	+0.543	.004	.010	3	2
LUNG_SCLC	Cyclopamine →	+0.760	+0.620	.002	.015	3	2
LUNG_SCLC	Cediranib →	+0.862	+0.473	.006	.016	3	2
BONE	AZD6094 →	-0.364	-1.162	.002	.038	3	2
BONE	Savolitinib →	-0.736	-1.727	.016	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSK1904529A by Somatic stem cell population maintenance activity — BONE

Explore this box plot interactively →