Peptidyl-lysine deacetylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-lysine deacetylation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO40, MOSPD2, and GCC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-lysine deacetylation activity versus FBXO40 in CCRCC (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FBXO40 →	+0.091	+0.229	.006	.002	3	3
GBM	MOSPD2 →	+0.325	+0.620	.005	.001	3	3
HNSC	GCC2 →	+0.506	+0.820	.001	.001	3	3
HNSC	EFHD1 →	+0.578	+0.724	.005	<.001	3	3
HNSC	CCN2 →	+1.106	+0.867	.004	<.001	3	3
HNSC	SMIM4 →	+0.578	+1.019	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034983 vs FBXO40 — CCRCC

Explore this scatter interactively →