Response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Response to endoplasmic reticulum stress pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR43_S77, SYNPO, and YME1L1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to endoplasmic reticulum stress activity versus WDR43_S77 in OV (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WDR43_S77 →	-0.673	-0.021	.001	.003	3	7
LSCC	SYNPO →	+0.282	+0.027	<.001	<.001	3	7
LSCC	YME1L1 →	-0.191	-0.025	<.001	.001	3	7
BRCA	PRKG1 →	+0.472	+0.029	<.001	<.001	3	7
BRCA	RPL11 →	-0.171	-0.023	.005	.003	3	6
COAD	RPS5 →	-0.185	-0.016	.004	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034976 vs WDR43_S77 — OV

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