Response to endoplasmic reticulum stress

Across TCGA cell cohorts, RNA activity of the Response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILF3, P4HB, and ERLEC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to endoplasmic reticulum stress activity versus ILF3 in STOMACH (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ILF3 →	-0.994	-0.181	.004	.001	3	6
BLOOD_Lymphoma	P4HB →	+1.132	+0.165	.005	.003	3	6
BLOOD_Lymphoma	ERLEC1 →	+1.332	+0.207	<.001	<.001	3	6
STOMACH	MEN1 →	-0.786	-0.210	.009	.001	2	6
PANCREAS	NAT10 →	-0.927	-0.105	.002	.003	3	5
PANCREAS	DPH7 →	-0.613	-0.154	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034976 vs ILF3 — STOMACH

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