Protein folding in endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Protein folding in endoplasmic reticulum pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP18, NONO, and DNAJC10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein folding in endoplasmic reticulum activity versus ARHGAP18 in OV (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ARHGAP18 →	+0.397	+0.052	<.001	.008	3	6
BRCA	NONO →	-0.156	-0.048	.003	.007	3	6
LUAD	DNAJC10 →	+0.418	+0.048	<.001	<.001	3	5
COAD	IGFBP2 →	+0.726	+0.031	.004	.001	3	5
LUAD	ACACA_S841 →	-0.888	-0.036	<.001	<.001	3	5
COAD	SCRIB →	-0.323	-0.042	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034975 vs ARHGAP18 — OV

Explore this scatter interactively →