Protein folding in endoplasmic reticulum

Across TCGA patient cohorts, RNA activity of the Protein folding in endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHPS, MAP4, and SPPL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein folding in endoplasmic reticulum activity versus DHPS in OV (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DHPS →	-0.711	-0.213	<.001	<.001	3	5
HNSC	MAP4 →	-0.555	-0.141	<.001	<.001	3	4
BRCA	SPPL3 →	-0.327	-0.147	<.001	<.001	3	4
BRCA	PKNOX1 →	-0.253	-0.166	.007	.002	3	4
CCRCC	SYT7 →	-0.302	-0.108	.006	.005	3	4
CCRCC	TSEN2 →	-0.308	-0.150	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034975 vs DHPS — OV

Explore this scatter interactively →