Protein folding in endoplasmic reticulum

Across TCGA cell cohorts, RNA activity of the Protein folding in endoplasmic reticulum pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CA2, GNG7, and MYO15B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CA2 grouped by Protein folding in endoplasmic reticulum-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CA2 →	+2.817	+1.007	.003	.003	3	3
BLOOD_Leukemia	GNG7 →	+1.550	+1.009	.004	.007	3	3
BLOOD_Leukemia	MYO15B →	+1.756	+1.040	.005	.004	3	3
CNS	FN3K →	+0.976	+0.964	.001	<.001	3	3
KIDNEY	FADD →	-0.410	-1.099	.004	.003	3	3
OVARY	PMM1 →	+0.842	+0.908	.007	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CA2 by Protein folding in endoplasmic reticulum activity — OVARY

Explore this box plot interactively →