Glutathione transmembrane transport

Across TCGA patient cohorts, RNA activity of the Glutathione transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEGF10, GJA1, and SLC2A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutathione transmembrane transport activity versus MEGF10 in GBM (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MEGF10 →	+1.011	+0.383	.002	.005	3	4
OV	GJA1 →	+1.330	+0.705	<.001	<.001	3	4
LSCC	SLC2A1 →	+1.246	+0.900	<.001	.001	3	4
LSCC	GPNMB →	+0.903	+0.985	<.001	<.001	3	4
LSCC	KRT6A →	+3.170	+1.003	<.001	.001	3	4
OV	TMEM158 →	+1.531	+0.689	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034775 vs MEGF10 — GBM

Explore this scatter interactively →