Glutathione transmembrane transport

Across TCGA cell cohorts, RNA activity of the Glutathione transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR52I1, PKIG, and CCL14, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR52I1 grouped by Glutathione transmembrane transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR52I1 →	+0.225	+1.721	.003	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	PKIG →	+0.334	+1.708	.003	<.001	3	3
SKIN	CCL14 →	+0.242	+0.474	.006	.006	3	3
SKIN	FIBCD1 →	+0.208	+0.474	.001	.006	3	3
LUNG_NSCLC_LUAD	NAA40 →	+0.163	+0.828	<.001	.009	3	3
OVARY	SCPEP1 →	+0.345	+1.229	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR52I1 by Glutathione transmembrane transport activity — OVARY

Explore this box plot interactively →