Glutathione transmembrane transport

Across TCGA cell cohorts, RNA activity of the Glutathione transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCC1, MAST4, and JAK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutathione transmembrane transport activity versus ABCC1 in LUNG_NSCLC_LUAD (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ABCC1 →	+1.214	+1.249	.005	<.001	3	5
LUNG_NSCLC_LUSC	MAST4 →	+1.756	+1.700	.006	<.001	3	3
OESOPHAGUS	JAK3 →	-0.597	-1.077	<.001	.005	3	3
LIVER	EFR3A →	+0.996	+1.858	.003	.002	3	3
LIVER	GABARAPL1 →	+1.250	+1.437	.001	.007	3	3
LIVER	SAMD8 →	+1.080	+1.760	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034775 vs ABCC1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →