Positive regulation of monoatomic ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of monoatomic ion transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTBP1, TEAD1, and DHX35, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LTBP1 grouped by Positive regulation of monoatomic ion transmembrane transport-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	LTBP1 →	+0.175	+0.121	.002	.001	3	6
LIVER	TEAD1 →	+0.864	+0.140	.002	.002	3	5
LARGE_INTESTINE	DHX35 →	-0.269	-0.094	.007	.003	3	5
LARGE_INTESTINE	MGAT4C →	-0.148	-0.087	.008	.009	3	5
SKIN	PRKACG →	-0.218	-0.052	.003	<.001	3	5
LUNG_NSCLC_LUAD	RPA2 →	+0.253	+0.055	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LTBP1 by Positive regulation of monoatomic ion transmembrane transport activity — BLOOD_Myeloma

Explore this box plot interactively →