Positive regulation of transmembrane transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXC11, IL6, and PDE1C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HOXC11 grouped by Positive regulation of transmembrane transport-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HOXC11 →	-0.242	-1.044	.001	.005	3	5
OVARY	IL6 →	-0.210	-0.784	<.001	.009	3	5
SOFT_TISSUE	PDE1C →	-0.277	-1.370	<.001	<.001	3	5
BLOOD_Myeloma	CAPN9 →	+0.187	+1.560	.001	<.001	3	4
SOFT_TISSUE	ADRM1 →	+0.311	+1.163	<.001	<.001	3	4
SOFT_TISSUE	TP53 →	-0.812	-1.063	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HOXC11 by Positive regulation of transmembrane transport activity — SOFT_TISSUE

Explore this box plot interactively →