Positive regulation of transmembrane transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYNCRIP, ZBTB24, and RAC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYNCRIP grouped by Positive regulation of transmembrane transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SYNCRIP →	+0.263	+0.044	.005	.006	3	5
LARGE_INTESTINE	ZBTB24 →	-0.150	-0.070	<.001	<.001	3	5
LARGE_INTESTINE	RAC1 →	+0.445	+0.058	.003	.004	3	5
LUNG_NSCLC_LUSC	TEAD1 →	+0.504	+0.092	<.001	.004	2	6
LUNG_NSCLC_LUSC	XRCC6 →	-0.259	-0.082	.006	<.001	3	5
CNS	RAP1GDS1 →	-0.245	-0.072	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYNCRIP by Positive regulation of transmembrane transport activity — BLOOD_Leukemia

Explore this box plot interactively →