Positive regulation of transmembrane transport

Across TCGA cell cohorts, RNA activity of the Positive regulation of transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, DDX60L, and CPA4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transmembrane transport activity versus ANXA2 in CNS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ANXA2 →	+2.042	+0.368	.007	<.001	3	10
LARGE_INTESTINE	DDX60L →	+2.172	+0.204	.001	.007	3	9
LIVER	CPA4 →	+4.611	+0.501	.001	.001	3	8
SKIN	MRPS25 →	-1.087	-0.233	.009	.004	3	8
BONE	SRPX2 →	+2.735	+0.282	<.001	.008	3	7
BREAST	CAV2 →	+4.013	+0.217	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034764 vs ANXA2 — CNS

Explore this scatter interactively →