Negative regulation of transmembrane transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R12C, SYNPO, and UBR5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transmembrane transport activity versus PPP1R12C in UCEC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP1R12C →	+0.447	+0.032	<.001	.002	3	8
HNSC	SYNPO →	+0.621	+0.037	<.001	.002	3	7
GBM	UBR5 →	-0.213	-0.045	<.001	<.001	3	7
OV	PRKG1 →	+0.546	+0.023	.004	.002	2	8
LSCC	RPP40 →	-0.276	-0.040	<.001	<.001	3	6
UCEC	RSU1 →	+0.437	+0.030	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034763 vs PPP1R12C — UCEC

Explore this scatter interactively →