Negative regulation of transmembrane transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, POLR3G, and NCAPH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transmembrane transport activity versus TTK in BRCA (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTK →	-0.785	-0.104	.002	.001	3	4
BRCA	POLR3G →	-0.583	-0.110	.006	.006	3	4
BRCA	NCAPH →	-0.759	-0.131	<.001	<.001	3	4
BRCA	ARHGEF39 →	-0.682	-0.148	<.001	<.001	3	4
BRCA	SHISAL1 →	+0.551	+0.110	<.001	.004	3	4
BRCA	FANCI →	-0.610	-0.134	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034763 vs TTK — BRCA

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