Negative regulation of transmembrane transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP7D1, PIGT, and CDC42EP3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of transmembrane transport activity versus MAP7D1 in BREAST (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAP7D1 →	+1.146	+0.297	<.001	<.001	3	9
LARGE_INTESTINE	PIGT →	+0.841	+0.184	<.001	<.001	3	7
STOMACH	CDC42EP3 →	+3.157	+0.229	.007	.009	3	7
LIVER	CD59 →	+2.008	+0.355	<.001	.001	3	7
LARGE_INTESTINE	DNTTIP1 →	+1.260	+0.258	<.001	<.001	3	6
LARGE_INTESTINE	PEA15 →	+1.554	+0.210	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034763 vs MAP7D1 — BREAST

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