Regulation of iron ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of iron ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the PAAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXP3, CORO1A, and IL4I1, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of iron ion transmembrane transport activity versus FOXP3 in PAAD (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	FOXP3 →	-0.713	-0.051	<.001	<.001	3	17
UVM	CORO1A →	-1.195	-0.046	<.001	.001	3	16
THYM	IL4I1 →	-1.323	-0.096	<.001	<.001	3	16
BLCA	CD86 →	-0.967	-0.056	<.001	<.001	3	16
BLCA	PLEK →	-1.134	-0.053	<.001	<.001	3	16
LAML	LILRB4 →	-1.322	-0.053	<.001	<.001	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034759 vs FOXP3 — PAAD

Explore this scatter interactively →