Regulation of iron ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of iron ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SDS, TCF25, and CA9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of iron ion transmembrane transport activity versus SDS in LUAD (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SDS →	-0.789	-0.103	<.001	<.001	3	4
GBM	TCF25 →	-0.234	-0.099	.002	.001	3	4
PDAC	CA9 →	+0.741	+0.075	<.001	.001	3	4
PDAC	BSG →	+0.265	+0.065	<.001	<.001	3	4
GBM	ATP7A_S270 →	+0.457	+0.102	.005	.002	3	4
GBM	TMEM179B →	+0.239	+0.069	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034759 vs SDS — LUAD

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