Regulation of iron ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of iron ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQGAP2, FGD2, and RASGRP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of iron ion transmembrane transport activity versus IQGAP2 in LSCC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IQGAP2 →	-0.486	-0.587	<.001	<.001	3	4
BRCA	FGD2 →	-0.526	-0.695	<.001	<.001	3	4
BRCA	RASGRP2 →	-0.533	-0.596	.003	.003	3	4
BRCA	FAM78A →	-0.514	-0.657	.001	.001	3	4
HNSC	SCML4 →	-0.647	-0.648	.003	.002	3	4
HNSC	P2RY14 →	-0.564	-0.457	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034759 vs IQGAP2 — LSCC

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