Iron ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Iron ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NELFCD, ZC3H18_S534, and YTHDC1_S308, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron ion transmembrane transport activity versus NELFCD in GBM (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NELFCD →	-0.272	-0.099	<.001	<.001	3	8
PDAC	ZC3H18_S534 →	-0.952	-0.048	<.001	<.001	3	8
PDAC	YTHDC1_S308 →	-1.619	-0.063	<.001	<.001	3	8
LSCC	PA2G4 →	-0.211	-0.056	<.001	<.001	3	8
GBM	RBM14_S582 →	-0.483	-0.121	.002	<.001	3	8
GBM	SRRM2_T1531 →	-0.241	-0.072	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034755 vs NELFCD — GBM

Explore this scatter interactively →