Iron ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Iron ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NGLY1, MDM2, and YIPF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Iron ion transmembrane transport activity versus NGLY1 in URINARY_TRACT (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NGLY1 →	+0.747	+0.393	.003	<.001	3	6
LUNG_NSCLC_LUAD	MDM2 →	+0.775	+0.124	.001	.001	2	7
URINARY_TRACT	YIPF2 →	-0.777	-0.466	<.001	<.001	3	5
BLOOD_Leukemia	TRIP10 →	-0.934	-0.100	.001	.002	3	4
URINARY_TRACT	HPRT1 →	+0.939	+0.398	.003	.001	3	4
BONE	FIGN →	-1.483	-0.284	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034755 vs NGLY1 — URINARY_TRACT

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