Nucleosome organization

Across TCGA patient cohorts, RNA activity of the Nucleosome organization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF14, SGO1, and KIFC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleosome organization activity versus KIF14 in OV (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KIF14 →	+0.933	+0.182	<.001	.001	3	5
OV	SGO1 →	+1.202	+0.325	<.001	<.001	3	5
OV	KIFC1 →	+1.234	+0.241	<.001	<.001	3	5
BRCA	TACC3 →	+1.229	+0.285	.003	.004	2	5
LUAD	MMS22L →	+1.289	+0.749	.009	.005	3	4
OV	CENPF →	+1.203	+0.225	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034728 vs KIF14 — OV

Explore this scatter interactively →