Nucleosome organization

Across TCGA cell cohorts, RNA activity of the Nucleosome organization pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDX19A, PLA2G4F, and LINC02693, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DDX19A grouped by Nucleosome organization-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DDX19A →	-0.602	-0.199	.003	.003	3	5
LARGE_INTESTINE	PLA2G4F →	+1.734	+0.260	<.001	<.001	3	5
BREAST	LINC02693 →	-0.949	-0.147	.007	.002	2	6
OESOPHAGUS	SMYD4 →	-0.587	-0.152	.005	.007	3	5
BONE	CDADC1 →	-0.883	-0.373	.003	.002	3	5
LARGE_INTESTINE	SNTA1 →	-1.339	-0.216	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DDX19A by Nucleosome organization activity — LIVER

Explore this box plot interactively →