Nucleosome organization

Across TCGA cell cohorts, RNA activity of the Nucleosome organization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGB2, H1-10, and CCNF, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleosome organization activity versus HMGB2 in LUNG_SCLC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HMGB2 →	+0.989	+0.189	.005	.003	3	9
LUNG_NSCLC_LUSC	H1-10 →	+2.012	+0.379	.005	.001	3	6
BLOOD_Myeloma	CCNF →	+1.010	+0.178	.008	.007	3	6
LARGE_INTESTINE	TMEM201 →	+0.631	+0.165	<.001	.001	3	6
OVARY	METAP2 →	+0.814	+0.261	.001	.002	3	6
KIDNEY	ATAD3A →	+1.062	+0.263	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034728 vs HMGB2 — LUNG_SCLC

Explore this scatter interactively →