Piecemeal microautophagy of the nucleus

Across TCGA patient cohorts, RNA activity of the Piecemeal microautophagy of the nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYH10, MMP2, and RAB23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Piecemeal microautophagy of the nucleus activity versus MYH10 in COAD (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MYH10 →	+0.380	+0.037	.003	.009	3	5
OV	MMP2 →	+0.629	+0.070	.001	.001	3	5
OV	RAB23 →	+0.366	+0.069	.006	<.001	3	5
BRCA	VCAN →	+0.708	+0.038	<.001	<.001	3	5
BRCA	HTRA1 →	+0.780	+0.038	<.001	<.001	3	5
BRCA	EIF3G →	-0.146	-0.044	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034727 vs MYH10 — COAD

Explore this scatter interactively →