Piecemeal microautophagy of the nucleus

Across TCGA patient cohorts, RNA activity of the Piecemeal microautophagy of the nucleus pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL34P26, HNRNPA1P35, and RNA5SP123, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Piecemeal microautophagy of the nucleus activity versus RPL34P26 in UCEC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL34P26 →	-0.831	-0.130	.008	.001	3	4
UCEC	HNRNPA1P35 →	-0.703	-0.109	.004	.007	3	4
GBM	RNA5SP123 →	-0.701	-0.282	<.001	<.001	3	4
GBM	SCGB2B2 →	-0.482	-0.235	<.001	.001	3	4
GBM	MPRIPP1 →	-0.376	-0.198	.001	.002	3	4
GBM	GEMIN7-AS1 →	-0.381	-0.338	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034727 vs RPL34P26 — UCEC

Explore this scatter interactively →