Piecemeal microautophagy of the nucleus

Across TCGA cell cohorts, RNA activity of the Piecemeal microautophagy of the nucleus pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RB1CC1, ATG7, and ATG13, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RB1CC1 grouped by Piecemeal microautophagy of the nucleus-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RB1CC1 →	-0.399	-1.222	<.001	<.001	3	10
BLOOD_Myeloma	ATG7 →	-0.410	-1.912	.005	<.001	3	8
OVARY	ATG13 →	-0.283	-1.128	.001	.002	3	7
SOFT_TISSUE	ULK2 →	-0.289	-1.221	.003	.007	1	9
LIVER	WIPI1 →	-0.186	-1.278	.007	<.001	3	5
OVARY	FRMPD1 →	+0.305	+1.265	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RB1CC1 by Piecemeal microautophagy of the nucleus activity — LARGE_INTESTINE

Explore this box plot interactively →